Seventy-two Grownup sufferers were randomly allocated to get both 0.02 mg/kg midazolam (Midazolam Team) or placebo (Handle Team) as premedication right before ESD. Sedation was completed by focusing on Modified Observer’s Evaluation of Alertness/Sedation (MOAA/S) scale of three or 4 with steady propofol infusion and bolus doses of fentanyl.